The Poison Pill Game is a two-player game where there are 21 counters (pills) in front of the players. Each player can take 1 or 2 ‘pills’ on their turn. The person who is left with the last pill on their turn must take it, and lose! To change the game, two players play but, each can take from 1 to 3 pills each time, and the one left with one pill loses.